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Single Particle Optical Sizing

The AccuSizer 780 uses the method of single-particle optical sizing   (SPOS) to quickly count and size a large number of particles, one at a   time, thus constructing the true particle size distribution (PSD).   This approach is in sharp contrast to "ensemble" methods, such as   laser   diffraction and sedimentation, which must process information   produced simultaneously by many particles. These alternative   techniques require the use of complex mathematical algorithms to   invert the data and yield only rough approximations of the PSD, with   limited accuracy and very   poor resolution. The AccuSizer determines   PSDs with resolution and   accuracy comparable to those produced by the   classical resistive-pore, or electrozone, method. The 780 does not   miss the "details", which are often critically important in   determining the quality of many products. A wider size range, higher   count rate, compatibility with any liquid or gas, and relative   immunity to clogging make it an instrument in a class all its own.

The   SPOS particle sizing method requires that concentrated suspensions be diluted, in order to eliminate particle coincidences in the sensing   photozone. Excessive dilution results in too low a count rate and poor statistical accuracy of the PSD, while overly concentrated suspensions     produce distortions in the distribution. The AccuSizer 780 uses   AutodilutionPat, which quickly and automatically dilutes the starting     sample to the optimum concentration, resulting in efficient and accurate     analysis. Trial-and-error manual dilution is eliminated, paving the   way   for single-keystroke operation; a complete analysis and flush   cycle can   be completed in less than 3 minutes.

The   780*s single particle sensitivity detects the important features in   the size distribution which other techniques usually miss. Single   particle optical sensing makes the measurement accurate, while   AutodilutionPat and leading-edge electronics make it fast and easy to   use. Trading off accuracy and resolution for speed and ease of use no   longer have to be   made with the AccuSizer 780.

The   AccuSizer 780 delivers reliable size and count data for even the   largest particles.A few outliers can spell the difference between   product success and failure; however traditional laser diffraction   particle size analyzers cannot detect large particle outliers in a sea   of smaller particles.The AccuSizer 780 reveals particle size   differences that previously went unnoticed.The 780 is a stable,   sensitive instrument that uses Single Particle Optical   Sizing (SPOS)   to count and size particles one at a time, eliminating   missed   particles while allowing:

  • Particle sensitivity of 10 PPT

  • Particle size accuracy of 2%

  • Particle count accuracy of 10%

Recently,an independent study proved that SPOS analyzers were 1,500 to 25,000     times more sensitive in detecting outliers than light scattering and accoustical sizing instruments.

The   AccuSizer 780 can also resolve fine particle distributions that are   directly related to the materials' properties. It is a proven and   valuable tool that laboratories around the world are   already using to   reformulate their product lines from R&D to production.

A modular solution to meet your most challenging applications

The   AccuSizer 780 AD Autodiluter is the cornerstone of the modular family   of instruments. The AccuSizer 780 AD incorporates a series of wide dynamic range sensors with a single stage exponential diluter to provide   a flexible high resolution, accurate, sensitive particle sizer. It     provides particle size information with unprecedented resolution and accuracy. It is especially suited to providing information on particle size distributions (PSDs) that are on scale but is not limited in the statistical information that it can provide on tails of mostly   submicron distributions. This patented module eliminates the need for   manual dilution of concentrated samples. Autodilution makes particle   size  analysis quick and easy, with no training required. Results are   highly reproducible.

AccuSizer 780/APS Automatic Particle Sizer

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The   APS has been called the bolder detector by many of our customers     because of its ability to detect low levels of aggregates several     standard deviations away from the mean of the distribution. Often these     aggregates are the difference between a good and bad sample. One     independent study showed the APS was 1,500 to 25,000 times more     sensitive in seeing outliers in the CMP slurry than commonly used laser     light scattering and acoustical sizing instruments. The same   sensitivity   will apply to other applications such as inks, pigments,   drug emulsions   where a few large particles spell the difference   between success and   disaster.

AccuSizer FX Focused Extinction

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The   AccuSizer FX is a new breed of particle size monitoring system   designed to go from the R&D lab to the process line with minimum   system   reconfiguration. The FX utilizes a patented focused beam   technology that   allows the sensor to focus on a specific area of the   flow channel to count and size individual particles at concentration   levels that are   hundreds of times higher than traditional sensors.   Although this type of   approach has been tried by other techniques it   has been plagued by low   resolution and accuracy. The new FX sensor   technology utilizes a   patented electro-optical configuration that   maintains the same levels of   resolution and accuracy found in   traditional SPOS sensors.

The AccuSizer 780/LVS Large Volume Sizer

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The   AccuSizer 780/LVS Large Volume Sizer is specifically designed to     analyze large volumes of liquid with particles as large as 2000   microns.   Often it is imperative to pass large amounts of diluted   dispersion   through an SPOS sensor. The key to the AccuSizer LVS system   is its large   volume dilution chamber that combines the ease of use of   autodilution   with the speed of a quick flushing fluidics system.
         The   AccuSizer 780/LVS allows the user to introduce a spoon   full of material   into the large volume dilution chamber and   immediately start taking   data. Ease of use of a fully automated   dilution system is combined with   SPOS to provide fast, high   resolution, high sensitivity particle size   distributions.

AccuSizer 780/SIS Syringe Injection Sampler

 

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When   volumetric sampling is paramount,   the SIS sampler fits the bill. With   syringes ranging from 0.5 to 25 ml   and a precision stepper motor with   over 25000 steps per pull the SIS   sampler is a perfect addition to the   family of modular instruments. It   is specifically suited to applications   in the pharmaceutical industry   such as USP <788> small and large   volume injectables. Now   available for use with the AccuSizer 780/SIS is   21 CFR Part 11   compliant software, Calibration and Validation SOPs.


AccuSizer 780/OL Online

Our     patented Autodilution technology has allowed us to take our   laboratory   instrumentation known for high precision, accuracy,   resolution and   reproducibility,and carry it to the

process     line. Simple customizable computer controlled fluid-sampling devices     are used to grab a precise aliquot of concentrated in-line dispersion     and automatically inject it into the Autodilution system. Then, just as     in our laboratory systems, the sample is diluted to the optimal     concentration for an SPOS measurement, without regard to its initial     concentration or particle size distribution (PSD). The resulting PSDs,     with unique single particle resolution are identical to those that     historically could only be obtained in the research laboratory. No     longer must correlation algorithms and complex statistical tools be     developed to compare laboratory findings with online results.

The     Autodilution module is an integral part of both of our laboratory     instruments- the AccuSizer 780 Single Particle Optical Sizer and the     Nicomp 380 Submicron Particle Sizer. These laboratory instruments have     been modified to meet the rigors imposed by online process monitoring.     They have been redesigned utilizing ruggedized com-ponents and are     housed in different classes of NEMA enclosures, depending on the     application. These vary from dust and waterproof enclosures to     explosion-proof modules that can handle even the most aggressive     environments, including high pressures and sub-zero temperatures.

Multi-port     systems are available with specialized software to monitor multiple     points in an online process. These reduce costs while maximizing     coverage to ensure that quality control requirements are met. Users have     a choice of using either an embedded mode Windows based controller or   a   Programmed Logic Controller (PLC) which are often found in process     control systems. In either case the resulting data can be displayed on     screen or passed to a Laboratory Information Management System (LIMS)   as   an ASCII file. It provides for limitless posbcapture data analysis   that   can easily be customized by the user with common programs found   on all   modern computer systems.

The     AccuSizer 780/OL system is able to detect minute amounts of oversized     particles in the tail of the process dispersion. It has produced   results   where the difference between a good and bad sample is   determined by a   few hundredths percent in volume fraction above a   particular critical   particle diameter, several standard deviations   above the main peak of   the distribution. It is also able to detect   very small percentages of   “fines” in the presence of larger particles.   These fines often play an   important role in determining the   viscosity, flowability and other   characteristics of both the process   dispersion and the final product.